:root {
   
    --max-width: 1280px;
    --gutter: 16px;
    
   
    --space-1: 4px;
    --space-2: 8px;
    --space-3: 12px;
    --space-4: 16px;
    --space-6: 24px;
    --space-8: 32px;
    
   
    --radius-card: 8px;
    --radius-modal: 12px;
    
   
    --shadow-subtle: 0 6px 18px rgba(0, 0, 0, 0.06);
    
   
    --timing-small: 180ms;
    --timing-medium: 300ms;
    --timing-large: 450ms;
    
   
    --font-family: 'Inter', system-ui, -apple-system, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;
    --font-size-base: 16px;
    --line-height: 1.4;
    
   
    --color-bg: #f6f7f9;
    --color-card: #ffffff;
    --color-primary: #0ea5a4;
    --color-secondary: #6b46c1;
    --color-text-primary: #0f1724;
    --color-text-secondary: #475569;
    --color-text-muted: #94a3b8;
    --color-border: #e2e8f0;
    --color-hover: #f1f5f9;
    
   
    --color-positive: #10b981;
    --color-negative: #ef4444;
    --color-warning: #f59e0b;
    --color-neutral: #64748b;
    
   
    --focus-ring: 3px solid rgba(14, 165, 164, 0.2);
}


* {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

body {
    font-family: var(--font-family);
    font-size: var(--font-size-base);
    line-height: var(--line-height);
    color: var(--color-text-primary);
    background-color: var(--color-bg);
}


.app-container {
    min-height: 100vh;
    display: flex;
    flex-direction: column;
}


.top-bar {
    height: 64px;
    display: flex;
    align-items: center;
    justify-content: space-between;
    padding: 0 var(--space-6);
    background-color: var(--color-card);
    box-shadow: var(--shadow-subtle);
    position: sticky;
    top: 0;
    z-index: 10;
}

.product-name {
    font-weight: 600;
    font-size: 20px;
    color: var(--color-primary);
}

.user-controls {
    display: flex;
    gap: var(--space-3);
}

.user-button {
    padding: var(--space-2) var(--space-3);
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    background: transparent;
    color: var(--color-text-secondary);
    cursor: pointer;
    transition: all var(--timing-small);
}

.user-button:hover {
    background-color: var(--color-hover);
}


.main-content {
    display: flex;
    max-width: var(--max-width);
    margin: 0 auto;
    padding: var(--space-6);
    gap: var(--space-6);
    flex: 1;
    width: 100%;
}


.filters-column {
    width: 320px;
    flex-shrink: 0;
}

.filters-container {
    background-color: var(--color-card);
    border-radius: var(--radius-card);
    padding: var(--space-6);
    box-shadow: var(--shadow-subtle);
}

.filters-container h2 {
    margin-bottom: var(--space-6);
    font-size: 18px;
    font-weight: 600;
}

.filter-group {
    margin-bottom: var(--space-6);
}

.filter-group label {
    display: block;
    margin-bottom: var(--space-2);
    font-size: 14px;
    font-weight: 500;
    color: var(--color-text-secondary);
}

.date-range {
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.date-input {
    flex: 1;
    padding: var(--space-2);
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
}

.select-input {
    width: 100%;
    padding: var(--space-2);
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    background-color: var(--color-card);
}

.chip-container {
    display: flex;
    flex-wrap: wrap;
    gap: var(--space-2);
}

.chip {
    padding: var(--space-1) var(--space-3);
    border: 1px solid var(--color-border);
    border-radius: 16px;
    font-size: 14px;
    cursor: pointer;
    transition: all var(--timing-small);
}

.chip:hover {
    background-color: var(--color-hover);
}

.chip.selected {
    background-color: var(--color-primary);
    color: white;
    border-color: var(--color-primary);
}

.quick-actions {
    display: flex;
    gap: var(--space-3);
    margin-top: var(--space-6);
}

.action-button {
    padding: var(--space-2) var(--space-4);
    border-radius: var(--radius-card);
    font-weight: 500;
    cursor: pointer;
    transition: all var(--timing-small);
    border: none;
}

.action-button.primary {
    background-color: var(--color-primary);
    color: white;
}

.action-button.primary:hover {
    opacity: 0.9;
}

.action-button.secondary {
    background-color: transparent;
    border: 1px solid var(--color-border);
    color: var(--color-text-secondary);
}

.action-button.secondary:hover {
    background-color: var(--color-hover);
}


.dashboard-column {
    flex: 1;
    display: flex;
    flex-direction: column;
    gap: var(--space-6);
}


.filter-preview {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: var(--space-3) var(--space-4);
    background-color: var(--color-card);
    border-radius: var(--radius-card);
    box-shadow: var(--shadow-subtle);
}

.applied-filters {
    display: flex;
    gap: var(--space-2);
}

.filter-tag {
    padding: var(--space-1) var(--space-2);
    background-color: var(--color-hover);
    border-radius: var(--radius-card);
    font-size: 14px;
    color: var(--color-text-secondary);
}

.clear-filters {
    background: none;
    border: none;
    color: var(--color-primary);
    font-size: 14px;
    cursor: pointer;
}


.kpi-row {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--space-4);
}

.kpi-card {
    background-color: var(--color-card);
    border-radius: var(--radius-card);
    padding: var(--space-6);
    box-shadow: var(--shadow-subtle);
    display: flex;
    align-items: center;
    position: relative;
}

.kpi-icon {
    font-size: 24px;
    margin-right: var(--space-4);
    width: 40px;
    height: 40px;
    display: flex;
    align-items: center;
    justify-content: center;
}

.kpi-icon i {
    font-size: 1.5rem;
}

.kpi-content {
    flex: 1;
}

.kpi-metric {
    font-size: 32px;
    font-weight: 700;
    line-height: 1.2;
}

.kpi-label {
    font-size: 14px;
    color: var(--color-text-secondary);
}

.kpi-trend {
    position: absolute;
    top: var(--space-4);
    right: var(--space-4);
    font-size: 14px;
    font-weight: 600;
    padding: var(--space-1) var(--space-2);
    border-radius: var(--radius-card);
}

.kpi-trend.positive {
    color: var(--color-positive);
    background-color: rgba(16, 185, 129, 0.1);
}

.kpi-trend.negative {
    color: var(--color-negative);
    background-color: rgba(239, 68, 68, 0.1);
}

.kpi-trend.neutral {
    color: var(--color-neutral);
    background-color: rgba(100, 116, 139, 0.1);
}


.charts-row {
    display: flex;
    gap: var(--space-4);
}

.chart-container {
    background-color: var(--color-card);
    border-radius: var(--radius-card);
    padding: var(--space-6);
    box-shadow: var(--shadow-subtle);
}

.chart-container.large {
    flex: 2;
}

.detail-panel {
    flex: 1;
    display: flex;
    flex-direction: column;
    gap: var(--space-4);
    background-color: var(--color-card);
    border-radius: var(--radius-card);
    padding: var(--space-6);
    box-shadow: var(--shadow-subtle);
}

.chart-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: var(--space-4);
}

.chart-title {
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.chart-title h3 {
    font-size: 16px;
    font-weight: 600;
}

.chart-icon {
    font-size: 18px;
    width: 24px;
    height: 24px;
    display: flex;
    align-items: center;
    justify-content: center;
}

.chart-icon i {
    font-size: 1rem;
}

.chart-controls {
    display: flex;
    gap: var(--space-2);
}

.time-range {
    padding: var(--space-1) var(--space-2);
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    font-size: 14px;
}

.export-button {
    padding: var(--space-1) var(--space-2);
    background-color: transparent;
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    font-size: 14px;
    cursor: pointer;
}

.export-button:hover {
    background-color: var(--color-hover);
}

.chart {
    height: 250px;
    margin-bottom: var(--space-4);
    position: relative;
}

.chart-legend {
    display: flex;
    justify-content: center;
    gap: var(--space-4);
}

.legend-item {
    display: flex;
    align-items: center;
    gap: var(--space-2);
    font-size: 14px;
    color: var(--color-text-secondary);
}

.legend-color {
    width: 12px;
    height: 12px;
    border-radius: 50%;
}


.table-container {
    background-color: var(--color-card);
    border-radius: var(--radius-card);
    padding: var(--space-6);
    box-shadow: var(--shadow-subtle);
}

.table-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: var(--space-4);
}

.table-header h3 {
    font-size: 18px;
    font-weight: 600;
}

.table-controls {
    display: flex;
    gap: var(--space-2);
}

.search-input {
    padding: var(--space-2) var(--space-3);
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    font-size: 14px;
}

.trials-table {
    width: 100%;
    border-collapse: collapse;
    font-size: 14px;
}

.trials-table th {
    text-align: left;
    padding: var(--space-3);
    border-bottom: 2px solid var(--color-border);
    color: var(--color-text-secondary);
    font-weight: 600;
}

.trials-table td {
    padding: var(--space-3);
    border-bottom: 1px solid var(--color-border);
}

.trials-table tr:hover {
    background-color: var(--color-hover);
}

.status-badge {
    display: inline-block;
    padding: var(--space-1) var(--space-2);
    border-radius: 12px;
    font-size: 12px;
    font-weight: 500;
}

.status-badge.active {
    background-color: rgba(16, 185, 129, 0.1);
    color: var(--color-positive);
}

.status-badge.warning {
    background-color: rgba(245, 158, 11, 0.1);
    color: var(--color-warning);
}

.status-badge.completed {
    background-color: rgba(107, 70, 193, 0.1);
    color: var(--color-secondary);
}

.actions {
    display: flex;
    gap: var(--space-1);
}

.icon-button {
    background: none;
    border: none;
    cursor: pointer;
    font-size: 16px;
    padding: var(--space-1);
    border-radius: var(--radius-card);
    width: 32px;
    height: 32px;
    display: flex;
    align-items: center;
    justify-content: center;
}

.icon-button i {
    font-size: 1rem;
    color: var(--color-text-secondary);
}

.icon-button:hover {
    background-color: var(--color-hover);
}

.table-pagination {
    display: flex;
    justify-content: center;
    align-items: center;
    margin-top: var(--space-6);
    gap: var(--space-2);
}

.pagination-button {
    padding: var(--space-2) var(--space-3);
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    background-color: transparent;
    cursor: pointer;
}

.pagination-button:hover {
    background-color: var(--color-hover);
}

.pagination-numbers {
    display: flex;
    gap: var(--space-2);
}

.pagination-number {
    width: 32px;
    height: 32px;
    display: flex;
    align-items: center;
    justify-content: center;
    border: 1px solid var(--color-border);
    border-radius: var(--radius-card);
    background-color: transparent;
    cursor: pointer;
}

.pagination-number:hover {
    background-color: var(--color-hover);
}

.pagination-number.active {
    background-color: var(--color-primary);
    color: white;
    border-color: var(--color-primary);
}


button:focus,
input:focus,
select:focus {
    outline: var(--focus-ring);
    outline-offset: 2px;
}


@media (max-width: 1024px) {
    .main-content {
        flex-direction: column;
    }
    
    .filters-column {
        width: 100%;
    }
    
    .kpi-row {
        grid-template-columns: repeat(2, 1fr);
    }
    
    .charts-row {
        flex-direction: column;
    }
    
    .chart-container.large,
    .detail-panel {
        flex: none;
    }
}

@media (max-width: 768px) {
    .kpi-row {
        display: flex;
        overflow-x: auto;
        padding-bottom: var(--space-4);
    }
    
    .kpi-card {
        min-width: 250px;
    }
    
    .trials-table {
        display: block;
        overflow-x: auto;
    }
}

@media (max-width: 480px) {
    .top-bar {
        padding: 0 var(--space-4);
    }
    
    .main-content {
        padding: var(--space-4);
    }
    
    .filter-preview {
        flex-direction: column;
        align-items: flex-start;
        gap: var(--space-2);
    }
    
    .applied-filters {
        flex-wrap: wrap;
    }
}